Institute of Good Manufacturing Practices India

(An Autonomous Body Recognized by Ministry of Commerce & Industry, Government of India)

Clinical Research Newsletter

02-10-2024

Pivotal phase-III FIBRONEER-IPF study of nerandomilast meets primary endpoint : Boehringer Ingelheim

Boehringer Ingelheim announced that the FIBRONEER-IPF trial successfully met its primary endpoint, demonstrating a significant change in Forced Vital Capacity (FVC) at

01-10-2024

Roche reports phase III CENTERSTONE study of Xofluza significantly decreases the transmission of influenza viruses

Roche has announced positive topline results from the phase III CENTERSTONE study of Xofluza (baloxavir marboxil), an antiviral drug that significantly reduces the tran

01-10-2024

Phase 1 trial of DS-9606 states promising preliminary clinical activity in advanced solid tumours patients

Initial results from the phase 1 trial of DS-9606 indicate promising clinical activity in patients with advanced solid tumors expressing Claudin-6 (CLDN6). Presented at

30-09-2024

Tectonic Therapeutic announces findings from Phase Ia trial of TX45

Tectonic Therapeutic has reported positive topline results from its Phase Ia trial of TX45, a treatment for Group 2 pulmonary hypertension-heart failure with preserved

30-09-2024

Aligos announces positive data from Phase IIa MASH treatment trial

Aligos Therapeutics has reported promising topline results from its Phase IIa HERALD clinical trial of ALG-055009, a thyroid hormone receptor beta agonist, aimed at tre

23-09-2024

Aura Biosciences declares positive results from phase 2 end of study of bel-sar for early-stage choroidal melanoma

Aura Biosciences, Inc., a biotechnology company focused on precision therapies for solid tumors, announced positive results from its Phase 2 trial evaluating bel-sar (A

21-09-2024

VYNE Therapeutics declares positive phase 1a SAD data for VYN202, a novel BD2-selective BET inhibitor

VYNE Therapeutics Inc. announced promising results from the single ascending dose (SAD) phase of its phase 1a trial for VYN202, an innovative oral BET inhibitor. This t

21-09-2024

Bayer reports detailed positive results from OASIS 3 phase III study of elinzanetant to treat VMS associated with menopause

Bayer recently presented detailed findings from the OASIS 3 phase III study at the 2024 annual meeting of The Menopause Society (TMS) in Chicago. The study demonstrated

21-09-2024

Acelyrin reported positive results from global phase 3 trial of izokibep in HS

Acelyrin, Inc., a late-stage clinical biopharmaceutical company, announced encouraging results from its global phase 3 clinical trial of izokibep for patients with mode

20-09-2024

Relay Therapeutics announces positive interim data for RLY-2608 emphasizing clinically meaningful progression free survival

Relay Therapeutics, Inc., a clinical-stage precision medicine company, shared promising interim data for RLY-2608, the first investigational allosteric, pan-mutant, and

18-09-2024

GSK reports positive headline data from phase II seasonal influenza mRNA vaccine programme

GSK plc announced positive results from a Phase II trial (NCT06431607) for its mRNA seasonal influenza vaccine program. The trial evaluated different mRNA formulations

18-09-2024

Merck documents positive top-line outcomes from phase 3 trial assessing efficacy and safety of Gardasil 9 in Japanese males

Merck (known as MSD outside the U.S. and Canada) reported positive top-line results from a Phase 3 trial (V503-064) evaluating Gardasil 9, a 9-valent HPV vaccine, in Ja

16-09-2024

Boehringer and CDR-Life announce data from geographic atrophy treatment trial

Boehringer Ingelheim and CDR-Life have announced positive results from the Phase I trial of BI 771716, a new treatment for geographic atrophy (GA), a severe form of lat

16-09-2024

Lilly’s efsitora reports positive results from Phase III type 2 diabetes trials

Eli Lilly and Company has announced promising results from Phase III trials of once-weekly insulin efsitora alfa (efsitora) for treating type 2 diabetes (T2D). The QWIN

15-09-2024

Vesper Bio announces data from Phase I frontotemporal dementia treatment trial

Vesper Bio has shared results from a Phase I study of VES001, a potential disease-modifying treatment for frontotemporal dementia (FTD) targeting patients with progranu

11-09-2024

Biogen’s higher Spinraza dose meets the key primary endpoints in Phase II/III trial

Biogen's higher dose of Spinraza (nusinersen) for spinal muscular atrophy (SMA) has met the primary endpoint in a Phase II/III DEVOTE study. The trial showed that infan

10-09-2024

Roche to showcase positive phase II FENopta OLE study data of BTK inhibitor, fenebrutinib for treating relapsing MS at 40th Congress of ECTRIMS

Roche will present new 48-week data from the phase II FENopta open-label extension (OLE) study of fenebrutinib at the ECTRIMS Congress in Copenhagen on September 18, 20

09-09-2024

Pfizer, Valneva announce positive phase 2 booster results of Lyme disease vaccine candidate

Valneva SE and Pfizer Inc. reported positive results from their VLA15-221 Phase 2 study of the Lyme disease vaccine candidate, VLA15. This study assessed the safety and

07-09-2024

RegenxBio highlights positive data for rare disease drug RGX-121

RegenxBio has announced positive long-term results from its pivotal study of RGX-121 for mucopolysaccharidosis type II (MPS II). The September 3 press release revealed

03-09-2024

Arrowhead to submit NDA after pivotal rare disease trial meets all key endpoints

Arrowhead Pharmaceuticals is preparing to file a New Drug Application (NDA) to the FDA following the release of full data from a key Phase III trial of its lead dr

03-09-2024

Valneva and Pfizer declare positive data of Lyme disease vaccine booster's trial

Valneva and Pfizer have announced positive results from the Phase II VLA15-221 trial, which tested a second booster dose of their Lyme disease vaccine candidate, VLA15,

03-09-2024

Bayer reports positive data from phase III FINEARTS-HF study of finerenone in patients with heart failure and LVEF at ESC Congress 2024

The Phase III FINEARTS-HF study revealed that finerenone (Kerendia/Firialta) significantly improved cardiovascular outcomes in heart failure (HF) patients with a left v

03-09-2024

HERCULES phase 3 study of tolebrutinib to treat non-relapsing secondary progressive MS meets key primary endpoint : Sanofi

Positive results from the HERCULES Phase 3 study showed that tolebrutinib, Sanofi’s oral brain-penetrant BTK inhibitor, significantly delayed disability progressi

03-09-2024

Ultromics’s EchoGo did not meet primary endpoint in heart disease trial

An AI tool developed by Ultromics showed lower accuracy compared to traditional clinical decision-making when identifying patients for further follow-ups, although it m

29-08-2024

Discontinued two Phase III Keytruda trials: MSD

Merck & Co (MSD) has discontinued two Phase III Keytruda (pembrolizumab) trials. The KEYNOTE-867 trial, testing Keytruda with stereotactic body radiation therapy (S

29-08-2024

Neurocrine announces positive data from Phase II schizophrenia treatment trial

Neurocrine Biosciences has reported positive results from its Phase II study of NBI-1117568, an oral schizophrenia treatment. The trial, NBI-‘568-SCZ2028, achieve

29-08-2024

Phase III trial of Leqvio in ASCVD patients meets key primary endpoints : Novartis

Novartis has announced that its Phase III V-MONO trial of Leqvio (inclisiran), an siRNA therapy, met its primary endpoints. The six-month, randomized, double-blind tria

29-08-2024

Aadi terminates 80% of staff after registrational Phase II trial fails

Aadi Biosciences is implementing cost-saving measures after halting its registrational Phase II PRECISION1 trial for the mTOR inhibitor nab-sirolimus. The Independent D

28-08-2024

Jazz’s cannabidiol therapy fails to meet endpoints in Japanese Phase III trial

Jazz Pharmaceuticals faced a setback in Japan as a Phase III trial for its cannabidiol therapy did not meet its primary endpoint. The study aimed to assess the oral can

24-08-2024

Innovo announces data from Phase II post-thyroidectomy scar treatment trial

Innovo Therapeutics has reported positive results from its Phase II clinical trial of INV-001, a treatment for reducing post-thyroidectomy scars. Conducted at four hosp

22-08-2024

Leo Pharma’s Timber reported Phase III failure

A year after investing in Timber Pharmaceuticals' pipeline, Leo Pharma has reported a Phase III failure for TMB-001, a topical isotretinoin ointment. The ASCEND trial (

21-08-2024

PainReform documents safety information from Phase III bunionectomy trial of PRF-110

Israel-based specialty pharmaceutical company PainReform has announced positive initial safety results from its Phase III bunionectomy trial of PRF-110, a post-surgical

19-08-2024

Sobi and Apellis exhibit positive topline outcomes from Phase III pegcetacoplan study

Sobi and Apellis Pharmaceuticals have released positive results from the Phase III VALIANT trial, evaluating pegcetacoplan for C3 glomerulopathy (C3G) and primary immun

19-08-2024

AN2 reduced its headcount by 50% after lead antibiotic fails in Phase II/III trial

AN2 Therapeutics has implemented cost-cutting measures following disappointing Phase II results from its Phase II/III trial of epetraborole, its lead antibiotic. The co

16-08-2024

Ultimovacs cancer vaccine fails to meet endpoints in Phase II trial for head and neck cancer

Following a recent trial failure, the future of Ultimovacs’ UV1 cancer vaccine now hinges on the Phase II DOVACC trial, with results expected in the first half of

16-08-2024

Aldeyra’s Reproxalap meets primary endpoint in Phase III clinical trial

Reproxalap has demonstrated enhanced efficacy in alleviating symptoms of dry eye disease and reducing ocular redness. Aldeyra Therapeutics has achieved the primary endp

13-08-2024

AstraZeneca declares positive data from chronic lymphocytic leukaemia therapy trial

AstraZeneca's Phase III AMPLIFY trial has reported positive results for Calquence (acalabrutinib) in treating chronic lymphocytic leukemia (CLL). This global, open-labe

13-08-2024

Phase IIa Alzheimer’s therapy trial meets primary efficacy endpoints : Longeveron

Longeveron has reported that the Phase IIa CLEAR MIND trial of Lomecel-B for mild Alzheimer’s disease successfully met its primary safety and secondary efficacy e

12-08-2024

Natera showcases positive results for Merkel cell carcinoma surveillance test

Natera has revealed data on its MRD test, Signatera, for detecting Merkel cell carcinoma, an aggressive skin cancer. Published in the Journal of Clinical Oncology, the

08-08-2024

Vaccinex reports positive data for SIGNAL-AD phase 1b/2 trial of pepinemab in Alzheimer

Vaccinex, Inc. announced positive early results from its SIGNAL-AD trial of pepinemab for Alzheimer’s disease (AD). Presented by Eric Siemers, MD, at the Alzheime

07-08-2024

Magnus Medical announces positive long-term data for neuromodulation system

Magnus Medical's study on its neuromodulation system, SAINT, showed positive results in treating treatment-resistant depression with sustained clinical benefits for up

07-08-2024

Eli Lilly declares positive data from Phase III HFpEF treatment trial

Eli Lilly has announced positive results from the Phase III SUMMIT trial of tirzepatide in adults with heart failure with preserved ejection fraction (HFpEF) and obesit

07-08-2024

PepGen declares positive data from Phase II trial of Duchenne muscular dystrophy

PepGen has announced positive results from the first dose cohort (5mg/kg) of its CONNECT1-EDO51 Phase II trial for PGN-EDO51, an investigational therapy for Duchenne mu

06-08-2024

Phase III FINEARTS-HF cardiovascular outcomes study of finerenone meets primary endpoint : Bayer

Bayer’s phase III FINEARTS-HF study has met its primary endpoint, demonstrating that finerenone significantly reduces cardiovascular death and heart failure (HF)

06-08-2024

Ultimovacs cancer vaccine fails in head and neck cancer's Phase II trial

Ultimovacs' UV1 cancer vaccine, combined with MSD’s Keytruda (pembrolizumab), failed to meet primary and secondary endpoints in the Phase II FOCUS trial (NCT05075

31-07-2024

Pfizer reports positive topline results from phase 3 AFFINE study of haemophilia A gene therapy candidate

Pfizer Inc. reported positive results from the Phase 3 AFFINE study (NCT04370054) of giroctocogene fitelparvovec, a gene therapy for adults with moderately severe to se

31-07-2024

Cytoki Pharma announces positive data from phase 1 study of lead lipidated IL-22 candidate, CK-0045 in obesity patients

Cytoki Pharma, ApS reported positive Phase 1 results for CK-0045, a lipidated IL-22 candidate, in healthy participants and those with obesity. The study evaluated CK-00

31-07-2024

Merck announces positive results from phase 2b/3 trial of clesrovimab, an investigational RSV preventative monoclonal antibody for infan

Merck (MSD outside the US and Canada) announced positive topline results from its phase 2b/3 trial (MK-1654-004) of clesrovimab (MK-1654), an investigational monoclonal

30-07-2024

ViiV Healthcare reports positive data demonstrating 2-drug regimen Dovato is as effective as 3-drug regimen Biktarvy for HIV-1's maintenance therapy

GSK plc's ViiV Healthcare released 48-week results from the PASO DOBLE Phase IV trial, comparing Dovato (dolutegravir/lamivudine [DTG/3TC]) to Biktarvy (bictegravir/emt

30-07-2024

Ionis Pharma reports positive results from HALOS study of ION582 in people with Angelman syndrome

Ionis Pharmaceuticals, Inc. reported positive results from the completed multiple ascending dose (MAD) phase 1/2 open-label study of ION582 in Angelman syndrome (AS) pa

30-07-2024

ViiV Healthcare reports positive data demonstrating 2-drug regimen Dovato is as effective as 3-drug regimen Biktarvy for HIV-1's maintenance therapy

GSK plc's ViiV Healthcare released 48-week results from the PASO DOBLE Phase IV trial, comparing Dovato (dolutegravir/lamivudine [DTG/3TC]) to Biktarvy (bictegravir/emt

29-07-2024

Roche’s RHONE-X extension study of Vabysmo meets all primary endpoints to treat diabetic macular edema

Roche has unveiled four-year data from the RHONE-X extension study, revealing that Vabysmo (faricimab) was well-tolerated in diabetic macular edema (DME) patients. The

28-07-2024

Phase III ARANOTE trial of darolutamide plus ADT meets primary endpoint in patients with mHSPC

The phase III ARANOTE trial found that darolutamide plus androgen deprivation therapy (ADT) significantly improved radiological progression-free survival (rPFS) in meta

28-07-2024

Roche declares positive phase I results of its oral GLP-1 receptor agonist CT-996 to treat people with obesit

Roche has announced positive results from two arms of the ongoing phase I ARANOTE trial for CT-996, an investigational, once-daily oral GLP-1 receptor agonist for treat

27-07-2024

Azafaros reports positive data from Phase II trial of nizubaglustat

Azafaros has announced positive results from the Phase II RAINBOW trial of nizubaglustat for treating GM2 gangliosidosis and Niemann-Pick disease type C (NPC). Conducte

21-07-2024

Roche announces positive data from Phase I obesity treatment trial

Roche has reported positive topline results from the Phase I CT-996-201 trial of CT-996, an oral GLP-1 receptor agonist for type 2 diabetes (T2D) and obesity. This tria

20-07-2024

Roche announces long-term data from diabetic macular oedema treatment trial

Roche has released four-year results from the RHONE-X extension study, which assessed the long-term safety and efficacy of Vabysmo (faricimab) for diabetic macular edem

19-07-2024

AVEO Oncology kidney cancer combo did not meet endpoints in Phase III

AVEO Oncology has reported mixed results from its recent trials. The Phase III TiNivo-2 trial (NCT04987203) did not achieve its primary endpoint of progression-free sur

19-07-2024

Teva declares positive data from Phase III paediatric migraine prevention trial

Teva Pharmaceutical has announced positive results from the Phase III SPACE trial of AJOVY (fremanezumab) for preventing episodic migraines in children and adolescents

19-07-2024

Alkeus publishes latest interim data from Stargardt disease therapy trial

Alkeus Pharmaceuticals has reported interim data from the TEASE-3 trial showing that gildeuretinol acetate effectively halts early-stage Stargardt disease progression.<

16-07-2024

AB Science reports positive Phase II Covid-19 data for masitinib

AB Science has reported positive results from its Phase II trial of masitinib in hospitalized Covid-19 patients, combined with isoquercetin. The treatment improved pati

15-07-2024

IDEAYA Biosciences announces positive data from Phase II trial of cancer treatment

Ideaya Biosciences, a US biotech firm, has released promising interim results from a Phase II trial of IDE397 for treating methylthioadenosine phosphorylase (MTAP) dele

15-07-2024

Zhiyi Biotech announces positive Phase I results for SK10 in CID treatment

Guangzhou Zhiyi Biotechnology (Zhiyi Biotech) has released promising findings from its Phase I clinical trial conducted in the US on SK10, a heat-killed form of Bactero

14-07-2024

Navidea discontinued rheumatoid arthritis programme after failed Phase III trial

Navidea Biopharma has dropped its rheumatoid arthritis (RA) program following disappointing results from the NAV3-33 trial's exploratory analysis. The Phase III study (

12-07-2024

Know Labs declares positive data for non-invasive diabetes screening device

Know Labs, based in the US, has released promising findings from a proof-of-concept trial evaluating its non-invasive device designed to detect blood sugar levels in di

12-07-2024

uniQure’s shares rise on positive data for Huntington’s gene therapy

UniQure's stock price has surged over 100% following positive interim results from Phase I/II trials of its gene therapy for Huntington’s disease. In the high-dos

08-07-2024

Johnson & Johnson declares positive results from phase 3 CARTITUDE-4 study of Carvykti to treat relapsed or lenalidomide-refractory multiple myeloma

Johnson & Johnson reported positive results from the phase 3 CARTITUDE-4 study's second interim analysis, comparing Carvykti (ciltacabtagene autoleucel; cilta-cel)

08-07-2024

Alvotech announces positive findings from study of denosumab biosimilar

Alvotech has reported positive topline data from the AVT03-GL-C01 study, evaluating AVT03 as a biosimilar to denosumab drugs Prolia and Xgeva. This randomized, double-b

07-07-2024

Mendel reports positive results in AI cohort matching trial

Mendel, a clinical AI firm, has announced results from a trial showing its Neuro-Symbolic system outperforms current models like GPT-4 in sorting patient cohorts from e

06-07-2024

Cartesian announces positive results from Phase IIb myasthenia gravis trial

Cartesian Therapeutics has declared positive results from its Phase IIb trial of Descartes-08, an autologous mRNA-engineered CAR-T therapy, in generalized myasthenia gr

06-07-2024

Tracon contemplates strategic options after sarcoma drug fails Phase II trial

TRACON Pharmaceuticals has discontinued its Phase II ENVASARC trial for envafolimab, a sarcoma therapy, due to inadequate efficacy findings that cannot support a biolog

05-07-2024

Roche’s phase II/III SKYSCRAPER-06 study of tiragolumab plus Tecentriq & chemotherapy in metastatic non-squamous NSCLC did not meet primary endpoints

Roche's phase II/III SKYSCRAPER-06 study evaluating tiragolumab with Tecentriq (atezolizumab) and chemotherapy as a first-line treatment for untreated non-squamous non-

03-07-2024

Noah Medical presents success of Galaxy surgical robotic system

Noah Medical, based in the US, has published promising results from a clinical study on its Galaxy surgical robotic system in the Asian Pacific Society of Respirology j

03-07-2024

Cartesian announces positive results from Phase IIb myasthenia gravis trial

Cartesian Therapeutics has reported promising findings from its Phase IIb trial evaluating Descartes-08, an autologous mRNA-engineered CAR-T cell therapy, in generalize

03-07-2024

Alvotech declares positive findings from study of denosumab biosimilar

Alvotech has announced positive top-line results from its confirmatory patient study, AVT03-GL-C01, evaluating AVT03 as a proposed biosimilar to denosumab drugs Prolia

03-07-2024

Johnson & Johnson declares data from Phase III multiple myeloma treatment trial

Johnson & Johnson (J&J) has announced positive results from the second interim analysis of the Phase III CARTITUDE-4 trial evaluating CARVYKTI (ciltacabtagene a

02-07-2024

INmune Bio’s unique Alzheimer’s trial endpoint gains validation

INmune Bio’s AD02 trial has successfully resumed following a previous FDA clinical hold, focusing on its primary endpoint, the Early Mild Alzheimer’s Cognit

30-06-2024

Sanofi declares positive data from Phase III EoE treatment trial

Sanofi reported positive Phase III trial results for Dupixent (dupilumab) in children aged one to eleven years with eosinophilic esophagitis (EoE). This trial assessed

25-06-2024

AstraZeneca’s trial of Imfinzi for lung cancer did not meet primary endpoint

AstraZeneca, a UK-based pharmaceutical company, has reported outcomes from the ADJUVANT BR.31 Phase III trial of Imfinzi (durvalumab), indicating that the trial did not

25-06-2024

Keymed reveals positive data of CM313 in immune thrombocytopenia trial

Keymed Biosciences has released promising results from a Phase I/II study of CM313 in adults with primary immune thrombocytopenia (ITP). This investigator-initiated, si

25-06-2024

Ethris releases positive data with mRNA drug following new funding

Ethris, a German biotech company, has released promising Phase I data on its intranasal mRNA candidate, ETH47. The trial (ISRCTN15391202) showed ETH47 administered nasa

24-06-2024

Vertex Pharma reports positive results from phase 1/2 study of VX-880 to treat type 1 diabetes

Vertex Pharmaceuticals presented new data from its phase 1/2 trial of VX-880, a stem cell-derived islet cell therapy, for type 1 diabetes (T1D) patients with severe hyp

24-06-2024

Alnylam reports positive Phase III results for rare heart disease drug vutrisiran

Alnylam Pharmaceuticals saw its stock rise by 32% following positive results from the late-stage study of its RNA interference (RNAi) therapy, vutrisiran, for treating

24-06-2024

Takeda reveals positive data from Phase IIb trial of ITP treatment

Takeda has reported positive results from its Phase IIb trial of mezagitamab (TAK-079) for primary immune thrombocytopenia (ITP), a rare bleeding disorder. This double-

08-06-2024

Alligator reveals positive data for pancreatic cancer drug

Alligator Bioscience shared positive results from its Phase Ib/II OPTIMIZE-1 trial (NCT04888312) for mitazalimab, a monoclonal antibody therapy targeting pancreatic can

08-06-2024

4DMT declares positive interim Phase I/II data for cystic fibrosis gene therapy

4DMT is advancing to Phase II of its AEROW trial following encouraging interim results for gene therapy 4D710 in cystic fibrosis (CF). Combining an AAV vector with a CF

08-06-2024

Advanced BioDesign declares positive data from ODYSSEY AML study

Advanced BioDesign has disclosed initial findings from its ODYSSEY trial, examining ABD-3001 (Sefaldin) efficacy in treating refractory acute myeloid leukemia (AML). AB

08-06-2024

Amgen declares positive results from phase 3 trial of Uplizna for treatment of immunoglobulin g4-related disease

Amgen shared positive results from its phase 3 trial (NCT04540497) on Uplizna (inebilizumab-cdon) for treating immunoglobulin G4-related disease (IgG4-RD).

08-06-2024

Takeda and Pfizer declare positive Phase III HD21 trial of ADCETRIS

Takeda and Pfizer have jointly announced positive outcomes from the Phase III HD21 trial, assessing ADCETRIS (brentuximab vedotin) combined with chemotherapy.

07-06-2024

AbbVie declares positive Phase II ovarian cancer trial data

AbbVie announced positive results from the Phase II PICCOLO trial of mirvetuximab soravtansine (ELAHERE) monotherapy in heavily pre-treated high folate receptor-alpha (

03-06-2024

J&J’s seltorexant declares positive results from Phase III MDD trial

Johnson & Johnson (J&J) has reported positive results from its Phase III trial of seltorexant in major depressive disorder (MDD), meeting all primary and second

01-06-2024

Gilead’s phase 3 TROPiCS-04 study of Trodelvy for treating locally advanced or metastatic urothelial cancer fails to meet primary endpoint

Gilead Sciences, Inc. released findings from the phase 3 TROPiCS-04 study in metastatic urothelial cancer (mUC), comparing Trodelvy (SG) to chemotherapy in patients who

01-06-2024

Innovent’s phase 3 study of picankibart for treating moderate to severe plaque psoriasis meets all primary and key secondary endpoints

Innovent Biologics, Inc., a renowned biopharmaceutical firm focusing on cancer, metabolic, autoimmune, and other diseases, has revealed the success of its phase 3 study

01-06-2024

Xeris Biopharma declares positive results from phase 2 study of investigational XeriSol-formulated once-weekly SC levothyroxine to treat hypothyroidism

Xeris Biopharma Holdings, Inc., a biopharmaceutical company dedicated to advancing patient care, has unveiled promising results from its phase 2 trial of XP-8121 for tr

01-06-2024

Ultragenyx reports topline results from phase 3 study of DTX401 gene therapy for glycogen storage disease type Ia

Ultragenyx Pharmaceutical Inc., dedicated to addressing rare genetic diseases, reported positive findings from its phase 3 GlucoGene study (NCT05139316) evaluating DTX4

29-05-2024

Amgen, AstraZeneca report positive results from phase 2a COURSE trial of Tezspire in patients with moderate to very severe COPD

Amgen and AstraZeneca released results from the phase 2a COURSE trial assessing Tezspire (tezepelumab-ekko) in individuals with moderate to very severe chronic obstruct

29-05-2024

Merus declares positive Phase II data for head and neck cancer antibody

Merus's bispecific antibody petosemtamab targets both epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5). Am

28-05-2024

Vicore Pharma declares positive results from phase 2a AIR trial of buloxibutid in idiopathic pulmonary fibrosis (IPF)

Vicore Pharma Holding AB unveiled positive final results from its phase 2a AIR trial evaluating buloxibutid (C21) in idiopathic pulmonary fibrosis (IPF) at the American

28-05-2024

Medtronic reports positive results from Affera Mapping and Ablation System with Sphere-9 Catheter to treat persistent AFib

Medtronic plc, a global healthcare technology leader, announced promising results from the SPHERE Per-AF study, evaluating the Affera Mapping and Ablation System with S

27-05-2024

GSK declares SWIFT-1 & SWIFT-2 phase III trials of depemokimab in patients with severe asthma meets primary endpoints

GSK plc reported positive outcomes from phase III trials SWIFT-1 and SWIFT-2, evaluating depemokimab's efficacy and safety in severe asthma with type 2 inflammation. Bo

27-05-2024

Nimbus declares positive data from Phase I/II solid tumour therapy trial

Nimbus Therapeutics has released encouraging results from its Phase I/II clinical trial of NDI-101150, an oral small-molecule inhibitor targeting hematopoietic progenit

21-05-2024

SPR Therapeutics announces positive data for PNS pain relief device

SPR Therapeutics announced positive results from a study evaluating its peripheral nerve stimulation (PNS) device for alleviating chronic knee pain post knee replacemen

20-05-2024

Vanda Pharmaceuticals declares positive data from motion sickness trial

Vanda Pharmaceuticals announced positive results from its Phase III trial of tradipitant for motion sickness, named Motion Serifos. The trial involved 316 participants

20-05-2024

Novo Nordisk reports positive results from Phase IIIa trial of haemophilia A drug

 Novo Nordisk has shared headline results from FRONTIER II, a Phase IIIa trial assessing subcutaneous Mim8 for haemophilia A treatment.

18-05-2024

AstraZeneca’s Phase III Covid-19 antibody trial meets primary endpoints

AstraZeneca reported successful results from its Phase III SUPERNOVA trial, evaluating sipavibart's efficacy in preventing Covid-19 among immunocompromised individuals.

18-05-2024

Roche targets obesity market with early positive trial data

Roche anticipates benefiting from the obesity therapy market following positive Phase Ib trial results for its investigational obesity and type 2 diabetes treatment, CT

13-05-2024

Boehringer declares positive findings from diabetic macular ischemia trial

Boehringer Ingelheim released positive findings from the HORNBILL Phase I/IIa trial assessing BI 764524, a humanized monoclonal anti-Sema3A antibody, for diabetic macul

12-05-2024

Teva and Medincell declared positive data for TEV-‘749 in schizophrenia trial

Teva and Medincell have disclosed positive outcomes from the Phase III Subcutaneous OLAnzapine Extended-Release Injection Study (SOLARIS), assessing TEV-‘749 (ola

11-05-2024

AngioDynamics touts positive data from AlphaVac trial

AngioDynamics has unveiled data showing the safety and efficacy of its AlphaVac F1885 System in patients with acute intermediate-risk pulmonary embolism (PE), demonstra

10-05-2024

Merck’s trial of Keytruda regimen fails to meet primary endpoint

Merck & Co (MSD) announced that its Phase III KEYNOTE-B21 trial, studying Keytruda with chemotherapy in newly diagnosed high-risk endometrial cancer post-surgery, d

09-05-2024

AstraZeneca declares positive interim data from mantle cell lymphoma trial

AstraZeneca's Phase III ECHO trial showed promising results for Calquence (acalabrutinib), a Bruton’s tyrosine kinase (BTK) inhibitor, combined with standard chem

08-05-2024

LEO Pharma declares positive data from Phase III plaque psoriasis trial

Leo Pharma has released promising findings from a Phase III clinical trial of Enstilar (LEO 90100) for Chinese adult patients with stable plaque psoriasis. Enstilar, an

07-05-2024

Micron reveals positive data from needle-free measles and rubella vaccine study

Micron Medical's Phase I/II trial, detailed in The Lancet, underscores the safety and efficacy of its measles and rubella microneedle patch (MNP), offering a needle-fre

07-05-2024

Micron Medical's Phase I/II trial, detailed in The Lancet, underscores the safety and efficacy of its measles and rubella microneedle patch (MNP), offering a needle-free vaccination option. Results sh

Micron Medical's Phase I/II trial, detailed in The Lancet, underscores the safety and efficacy of its measles and rubella microneedle patch (MNP), offering a needle-free vaccination option. Results

07-05-2024

Newron’s add-on schizophrenia therapy mets endpoints in Phase II/III trial

Newron Pharmaceuticals' evenamide study has achieved its primary endpoint, demonstrating improvement in positive and negative symptoms, and severity in patients with tr

06-05-2024

Biological E declares positive results from phase-III trials of Pneubevax 14 in 6-8-week old infants

Biological E. Limited (BE), based in Hyderabad, disclosed phase-III trial results for its 14-Valent Pneumococcal Conjugate Vaccine (PCV), Pneubevax 14 (BE-PCV-14), in V

05-05-2024

Merck’s phase 3 KEYNOTE-811 trial of Keytruda in combo with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy meets dual primary endpoint of OS in patients with HER2-positive ad

Merck, known as MSD outside the US and Canada, announced that its phase 3 trial KEYNOTE-811 evaluating Keytruda (pembrolizumab) with trastuzumab and chemotherapy met it

30-04-2024

Neurocrine declares positive Phase II trial results for NBI-1065845

Neurocrine Biosciences reports positive findings from the Phase II SAVITRI trial of NBI-1065845 for major depressive disorder (MDD) in adults.

30-04-2024

Kintor Pharma’s GT20029 Phase II trial meets primary endpoint

Kintor Pharma has announced positive results from its GT20029 Phase II trial in China for treating male androgenetic alopecia (AGA), meeting the primary endpoint.

30-04-2024

Addex Therapeutics: Phase 2 epilepsy study of ADX71149 fails to meet primary endpoint

Addex Therapeutics, a clinical-stage biopharmaceutical company, disclosed phase 2 epilepsy study results for adjunctive ADX71149 (JNJ-40411813) in patients with inadequ

30-04-2024

AstraZeneca, Daiichi Sankyo report positive results from DESTINY-Breast06 phase III trial of Enhertu

The DESTINY-Breast06 phase III trial unveiled positive outcomes, showing Enhertu's (trastuzumab deruxtecan) significant progression-free survival (PFS) improvement

30-04-2024

Merck declares positive results from trial of pneumonia vaccine

German pharmaceutical company Merck KGaA (Merck) has reported positive results from its Phase III STRIDE-10 trial of V116, a pneumococcal conjugate vaccine aimed at pre

28-04-2024

Alto Neuroscience declares positive ALTO-101 Phase I trial results

Alto Neuroscience has reported positive results from its Phase I trial of ALTO-101, a PDE4 inhibitor for treating cognitive impairment in schizophrenia (CIAS). The stud

27-04-2024

Gain declares positive Phase I results for Parkinson’s therapy

In February, Gain Therapeutics revealed preclinical data indicating that GT-02287 restored motor function and significantly reduced plasma neurofilament light chain (Nf

20-04-2024

Joincare Pharmaceutical meets primary endpoint in Phase III flu trial

Joincare Pharmaceutical, based in China, has achieved the primary endpoint in a Phase III trial for its flu candidate TG-1000, in collaboration with Taiwan's TaiGen Bio

20-04-2024

GSK declares positive data from Phase III gonorrhoea antibiotic trial

GSK has reported favorable outcomes from the Phase III EAGLE-1 clinical trial of gepotidacin, an oral bactericidal triazaacenaphthylene antibiotic, in treating uncompli

20-04-2024

Marinus did not meet early stopping criteria for status epilepticus trial

Marinus Pharmaceuticals announced that its Phase III RAISE study (NCT04391569) of IV ganaxolone for status epilepticus (SE) didn't meet early stopping criteria. They pl

19-04-2024

Barinthus meets primary endpoint in Phase I/II trial of HPV therapy

Barinthus Biotherapeutics (formerly Vaccitech) released topline data from its Phase Ib/II APOLLO trial for HPV treatment, VTP-200. The randomized APOLLO trial (NCT04607

19-04-2024

Cerevel declares positive data from Phase III Parkinson’s treatment trial

Cerevel Therapeutics released positive Phase III TEMPO-3 trial results for tavapadon in Parkinson's disease. Tavapadon, a D1/D5 receptor partial agonist, showed efficac

14-04-2024

Acadia’s schizophrenia drug trial did not meet primary endpoint

US-based biopharmaceutical company Acadia Pharmaceuticals has announced that its Phase III ADVANCE-2 clinical trial evaluating pimavanserin for the treatment of negativ

14-04-2024

Enlivex declares positive data from Phase II sepsis treatment trial

Enlivex Therapeutics has disclosed promising top-line results regarding safety and efficacy from its Phase II clinical trial evaluating Allocetra, an off-the-shelf cell

14-04-2024

Teva’s Ajovy hits endpoint in Chinese Phase III Trial for Migraine Prevention

Teva Pharmaceuticals has released encouraging results from a Phase III trial assessing Ajovy (fremanezumab) for migraine prevention in Chinese adult patients.

14-04-2024

Amylyx reports positive results for failed ALS drug in Wolfram trial

Amyyx Pharmaceuticals has released promising interim results from its Phase II trial of Relyvrio (AMX0035) for Wolfram syndrome, a rare disease.

13-04-2024

NeuroGenesis declares positive data from multiple sclerosis trial

NeuroGenesis Bio's interim analysis of a Phase II clinical trial extension for NG-01 in progressive MS yielded promising results. NG-01, the company's lead candidate, i

10-04-2024

AstraZeneca reports positive results from the ADRIATIC phase III trial of Imfinzi in patients with limited-stage small-cell lung cancer

The ADRIATIC phase III trial unveiled promising results indicating AstraZeneca’s Imfinzi (durvalumab) significantly enhanced overall survival (OS) and progression

10-04-2024

Viking declares positive data from Phase I oral obesity treatment trial

Viking Therapeutics has reported positive data from its Phase I multiple ascending dose (MAD) clinical trial of VK2735, an oral tablet under investigation for treating

10-04-2024

Phase III trial of KRAZATI meets endpoints : Bristol Myers Squibb

Bristol Myers Squibb (BMS) disclosed positive results from its Phase III KRYSTAL-12 trial of KRAZATI (adagrasib) for treating non-small cell lung cancer (NSCLC) with KR

10-04-2024

Moderna: Phase III Covid-19 vaccine trial meets primary endpoints

Moderna has disclosed promising interim findings from the Phase III NextCOVE clinical trial, demonstrating the efficacy of its next-generation COVID-19 vaccine candidat

10-04-2024

LENZ declares positive results from presbyopia treatment trial

LENZ Therapeutics disclosed positive results from the Phase III CLARITY study assessing aceclidine formulations, LNZ100 and LNZ101, for presbyopia treatment.

09-04-2024

HealthNet Global presents a ground-breaking Tele-ICU Programme at Apollo Spectra Hospitals, Delhi

HealthNet Global (HNG) introduces its Tele-ICU program at the inauguration of Apollo Spectra Hospital in Pusa Road, Delhi, marking a significant advancement in critical

31-03-2024

Pfizer declares positive results from phase 3 trial of Adcetris regimen in relapsed/refractory DLBCL patients

Pfizer Inc. has announced positive results from a phase 3 trial of Adcetris (brentuximab vedotin) in combination with lenalidomide and rituximab for relapsed/refractory

31-03-2024

Aurobindo Pharma arm CuraTeQ reports omalizumab biosimilar candidate BP11 meets phase 1 trial endpoints

CuraTeQ Biologics Private Limited, a subsidiary of Aurobindo Pharma Ltd, announced that their omalizumab biosimilar candidate BP11 met phase 1 trial endpoints compared

31-03-2024

OcuTerra’s Phase II diabetic retinopathy trial misses endpoints

OcuTerra Therapeutics reported that its Phase II DREAM trial of nesvategrast (OTT166) eye drops for diabetic retinopathy (DR) didn't meet endpoints. The study aimed to

30-03-2024

Bristol Myers Squibb reports CheckMate -9DW trial of Opdivo plus Yervoy meets primary endpoint of OS to treat advanced HCC

Bristol Myers Squibb has announced positive findings from the phase 3 CheckMate -9DW trial, evaluating Opdivo (nivolumab) plus Yervoy (ipilimumab) as first-line therapy

30-03-2024

Nuvectis Pharma reports positive preliminary data from NXP800 phase 1b trial in ovarian cancer (platinum-resistant ARID1a-mutated)

Nuvectis Pharma, Inc., a biopharmaceutical company, shared positive preliminary findings from a phase 1b trial of NXP800 for platinum-resistant ARID1a-mutated ovarian c

22-03-2024

Ionis Pharma reports positive results from the phase 2 study of ION224, demonstrating clinical efficacy in treating NASH/MASH

Ionis Pharmaceuticals, Inc. has released positive outcomes from a phase 2 trial of ION224, an investigational DGAT2 antisense inhibitor targeting metabolic dysfunction-

21-03-2024

GSK reports positive results from DREAMM-8 phase III trial for Blenrep vs standard of care combination in relapsed/refractory MM

GSK plc announced positive interim results from the DREAMM-8 phase III trial, comparing Blenrep (belantamab mafodotin) plus pomalidomide and dexamethasone (PomDex) agai

21-03-2024

Phase II KARDIA-2 study of zilebesiran in people with hypertension meets primary endpoint: Roche & Alnylam

Roche and Alnylam reported positive results from the phase II KARDIA-2 trial [NCT05103332] of zilebesiran, an investigational RNAi therapy for hypertension, a primary c

21-03-2024

BlueRock Therapeutics reports positive 18-month data from phase I trial for bemdaneprocel in Parkinson’s disease

Bayer AG and BlueRock Therapeutics LP, an independently operated subsidiary of Bayer AG, have disclosed 18-month data from a phase I clinical trial on bemdaneprocel, an

21-03-2024

MAIA Biotechnology declares positive data from NSCLC therapy trial

MAIA Biotechnology has released positive efficacy results from its Phase II THIO-101 trial, examining THIO combined with cemiplimab (Libtayo) for advanced non-small cel

16-03-2024

Viking Therapeutics, Inc. reported positive outcomes from its phase 2 trial of VK2735, a dual GLP-1 and GIP receptor agonist for metabolic disorders

Viking Therapeutics, Inc. (Viking), a clinical-stage biopharmaceutical company specializing in metabolic and endocrine disorder treatments, reported positive outcomes f

16-03-2024

GSK reports positive results for gepotidacin in uncomplicated urogenital gonorrhoea from EAGLE-1 phase III trial

GSK plc announced positive outcomes from the pivotal EAGLE-1 phase III trial of gepotidacin, an oral antibiotic targeting urogenital gonorrhea in adults and adolescents

16-03-2024

Biodexa reports an R&D update including positive results from the phase I trial of MTX110 in patients with diffuse midline glioma

Biodexa Pharmaceuticals PLC, a clinical-stage biopharmaceutical company, shares an R&D update. Positive top-line results from a recent phase 1 trial of MTX110 in di

15-03-2024

Bristol Myers Squibb declares positive results of Zeposia from phase 3 DAYBREAK open-label extension trial in patients with MS (relapsing forms)

Bristol Myers Squibb revealed findings from the phase 3 DAYBREAK trial, demonstrating Zeposia's (ozanimod) enduring efficacy and safety in relapsing forms of multiple s

15-03-2024

Cynata Therapeutics declares inspiring initial data from the phase 1 trial of CYP-006TK to treat a diabetic foot ulcer

Cynata Therapeutics Limited, a biotech firm specializing in cell therapeutics, completed the initial analysis of wound surface area in the first 16 patients of its phas

07-03-2024

Novartis proposes positive data from the SMART study of Zolgensma in older and heavier children with SMA at the 2024 MDA conference

Novartis revealed new data affirming the clinical advantages of Zolgensma (onasemnogene abeparvovec), the sole one-time gene therapy for spinal muscular atrophy (SMA).<

07-03-2024

Ultimovacs declares trial results of UV1 cancer vaccine.

Ultimovacs, a biotechnology company in its clinical stages, has unveiled data from the Phase II NIPU trial on the UV1 cancer vaccine, focusing on mesothelioma. This tri

07-03-2024

Pfizer notifies top-line results from Phase III RSV vaccine trial

Pfizer's Phase III RENOIR trial reveals top-line data on its respiratory syncytial virus (RSV) vaccine, ABRYSVO, targeting RSV-related lower respiratory tract disease (

06-03-2024

ViiV Healthcare demonstrates positive findings from the phase I study of cabotegravir long-acting injectable investigational formulation

GSK plc and ViiV Healthcare, a specialized HIV company majority-owned by GSK with Pfizer and Shionogi as shareholders, announced positive phase I study results for cabo

06-03-2024

CASI and BioInvent declare positive data from lymphoma treatment trial

CASI Pharmaceuticals and BioInvent International unveiled positive initial efficacy findings from their Phase I trial of BI-1206 in relapsed/refractory indolent non-Hod

26-02-2024

Sanofi communicates positive results from trial of frexalimab for multiple sclerosis (MS)

Sanofi, a French pharmaceutical company, is developing frexalimab under an exclusive license from ImmuNext. Positive Phase II trial results were recently announced for

26-02-2024

Hemab notifies positive Phase I Glanzmann thrombasthenia therapy data

HMB-001 is assessed as a prophylactic treatment for a bleeding disorder, Glanzmann thrombasthenia. Hemab Therapeutics has unveiled encouraging preliminary data from the

25-02-2024

Phase III thyroid eye disease trial of Innovent fulfils primary endpoint

The antibody IBI311 showed favorable safety in Thyroid Eye Disease (TED) patients. Innovent Biologics disclosed positive results from the Phase III RESTORE-1 trial in C

25-02-2024

UroMems declares positive results for stress urinary incontinence implant

Stress urinary incontinence, marked by urine leakage during activities like exercise or sneezing, is the focus of UroMems' latest trial evaluating its UroActive device.

24-02-2024

NeuroSense expands data in Phase IIb ALS study with positive update

Symptoms of amyotrophic lateral sclerosis (ALS) include hand and arm motor control loss and limb usage impairment. NeuroSense released additional top-line data from its

20-02-2024

AstraZeneca’s Tagrisso exhibited overwhelming efficacy benefit for patients with unresectable, stage III EGFR-mutated lung cancer in LAURA phase III trial

The LAURA phase III trial highlights AstraZeneca's Tagrisso (osimertinib) as a promising intervention, demonstrating a statistically significant improvement in progress

20-02-2024

Tharimmune’s buccal film liver drug exhibits efficacy in Phase I trial

Tharimmune, a US biotech firm, has unveiled promising data on TH104, a transmucosal buccal film designed for liver-related and inflammatory conditions. TH104 targets ai

20-02-2024

Sanofi and Denali’s ALS therapy misses preliminary endpoint in Phase II trials

Sanofi and Denali Therapeutics' ALS therapy, SAR443820/DNL788, didn't meet its primary endpoint in the Phase II HIMALAYA trial. The trial aimed to gauge its effect on t

15-02-2024

Grifols registers positive topline outcomes from phase 3 fibrinogen clinical tr

Grifols, a leading producer of plasma-derived medicines, announced positive results from Biotest's phase 3 trial of fibrinogen concentrate (FC), BT524, for acquired fib

15-02-2024

Grifols documents positive topline outcomes from the phase 3 fibrinogen clinical trial

Grifols, a global leader in plasma-derived medicines, celebrates Biotest's phase 3 trial success with BT524, a fibrinogen concentrate (FC) for acquired fibrinogen defic

10-02-2024

Beacon registers positive 12-month data from phase 2 SKYLINE trial of AGTC-501 in patients with X-linked retinitis pigmentosa

Beacon Therapeutics Holdings Limited, a leading ophthalmic gene therapy company, presented interim results from the phase 2 SKYLINE trial for X-linked retinitis pigment

10-02-2024

Chugai Pharma’s mosunetuzumab accomplishes the primary endpoint in expansion cohort of the Japanese phase I trial for r/r follicular lymphoma

Chugai Pharmaceutical Co., Ltd. announced that the anti-CD20/CD3 bispecific antibody mosunetuzumab met the primary endpoint of complete response rate (CRR) in a Japanes